Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
8
We explored the impact of the probiotic I-3856 on managing irritable bowel syndrome with predominant constipation (IBS-C) through a thorough eight-week randomized, double-blind study involving 456 participants.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
Most Useful Reviews
7.5
Regular bowel function
1 people found this helpful
After three days of taking this, I noticed that my bowel movements occurred every two days, and I overall felt very good.
6
Detox and energy boost
2 people found this helpful
I purchased this to detoxify, as my eating habits had become poor. I noticed improvements in my bowel movements and felt less fatigued. While it might just be my perception, I genuinely believe my body is feeling a bit more energised.
9
Effective cleansing tool
This product is superb for maintaining regular bowel function and for detoxifying the body. It effectively accomplishes the cleansing task. Your support by clicking Yes if this review was helpful is appreciated. Thank you!
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
9
We investigated how saccharomyces cerevisiae affects gut motility in rats undergoing repeated water avoidance stress, simulating diarrhea-predominant irritable bowel syndrome.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
8
We explored the impact of the probiotic I-3856 on managing irritable bowel syndrome with predominant constipation (IBS-C) through a thorough eight-week randomized, double-blind study involving 456 participants.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
8
We examined the impact of CNCM I-3856 supplementation on irritable bowel syndrome (IBS) by analyzing data from two clinical trials involving 579 participants.
Our findings revealed notable improvements in abdominal pain and bloating among those taking CNCM I-3856 during the second month of treatment.
Participants in the active group showed better stool consistency and higher odds of symptom relief compared to those taking a placebo.
However, there were no significant differences at the end of the study, indicating mixed results on long-term benefits of this treatment for IBS.
Our findings revealed notable improvements in abdominal pain and bloating among those taking CNCM I-3856 during the second month of treatment.
Participants in the active group showed better stool consistency and higher odds of symptom relief compared to those taking a placebo.
However, there were no significant differences at the end of the study, indicating mixed results on long-term benefits of this treatment for IBS.
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Regular bowel function
1 people found this helpful
After three days of taking this, I noticed that my bowel movements occurred every two days, and I overall felt very good.
6
Detox and energy boost
2 people found this helpful
I purchased this to detoxify, as my eating habits had become poor. I noticed improvements in my bowel movements and felt less fatigued. While it might just be my perception, I genuinely believe my body is feeling a bit more energised.
9
Effective cleansing tool
This product is superb for maintaining regular bowel function and for detoxifying the body. It effectively accomplishes the cleansing task. Your support by clicking Yes if this review was helpful is appreciated. Thank you!
7.5
Improves bowel function
Good quality supplement. NAC aids in maintaining bodily health and detoxification, while selenium adds further benefits. The capsules are easy to swallow, with an optimal dosage per capsule. The packaging is satisfactory, and the product supports normal bowel function and enhances overall well-being.
6
Rebuilds intestinal walls
This supplement is excellent for cleansing the body and liver, promoting normal bowel function while also aiding in repairing the intestinal wall. It also assists with respiratory issues, softening and removing mucus from the lungs. It performs its functions well.
Frequently Asked Questions
7.5
Regular bowel function
1 people found this helpful
After three days of taking this, I noticed that my bowel movements occurred every two days, and I overall felt very good.
6
Detox and energy boost
2 people found this helpful
I purchased this to detoxify, as my eating habits had become poor. I noticed improvements in my bowel movements and felt less fatigued. While it might just be my perception, I genuinely believe my body is feeling a bit more energised.
6
Improves bowel movements
25 people found this helpful
Initially, I experienced nausea for three days, making me feel unwell, and my appetite diminished. However, as I continued, my bowel movements became easier and more regular, which was quite miraculous. Drinking plenty of mineral water helped during this process.
9
Effective cleansing tool
This product is superb for maintaining regular bowel function and for detoxifying the body. It effectively accomplishes the cleansing task. Your support by clicking Yes if this review was helpful is appreciated. Thank you!
7.5
Improves bowel function
Good quality supplement. NAC aids in maintaining bodily health and detoxification, while selenium adds further benefits. The capsules are easy to swallow, with an optimal dosage per capsule. The packaging is satisfactory, and the product supports normal bowel function and enhances overall well-being.
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
8
We explored the impact of the probiotic I-3856 on managing irritable bowel syndrome with predominant constipation (IBS-C) through a thorough eight-week randomized, double-blind study involving 456 participants.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
9
We investigated how saccharomyces cerevisiae affects gut motility in rats undergoing repeated water avoidance stress, simulating diarrhea-predominant irritable bowel syndrome.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
8
We examined the impact of CNCM I-3856 supplementation on irritable bowel syndrome (IBS) by analyzing data from two clinical trials involving 579 participants.
Our findings revealed notable improvements in abdominal pain and bloating among those taking CNCM I-3856 during the second month of treatment.
Participants in the active group showed better stool consistency and higher odds of symptom relief compared to those taking a placebo.
However, there were no significant differences at the end of the study, indicating mixed results on long-term benefits of this treatment for IBS.
Our findings revealed notable improvements in abdominal pain and bloating among those taking CNCM I-3856 during the second month of treatment.
Participants in the active group showed better stool consistency and higher odds of symptom relief compared to those taking a placebo.
However, there were no significant differences at the end of the study, indicating mixed results on long-term benefits of this treatment for IBS.
References
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. doi:10.12669/pjms.40.3.8349
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. doi:10.7717/peerj.14390
- Mourey F, Decherf A, Jeanne JF, Clément-Ziza M, Grisoni ML, et al. I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol. 2022;28:2509. doi:10.3748/wjg.v28.i22.2509
- Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35:139. doi:10.1007/s00384-019-03462-4
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. doi:10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. doi:10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. doi:10.1016/j.dld.2014.11.007
